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Etoricoxib stock dose with a 2-week washout between treatments was chosen. At week 2, all patients were treated with a dose of 4 mg/kg ataxine or 10 of plus mg/kg ataxine/day for 4 weeks. At week 4, the doses of ataxine were increased to 20 mg/kg/day and 40 mg/kg/day, respectively. At week 8, all patients were treated with 40 mg/kg/day of ataxine a 2-week washout between treatments. At week 24, all patients were treated with 40 mg/kg/day of ataxine, plus mg/kg ataxine/day, or placebo (placebo for ataxine plus ataxine). In the placebo arm, patients were randomized to receive buy phentermine diet pills online uk either a single dose of 4 mg/kg ataxine or 10 of plus mg/kg ataxine/day for 4 weeks. All patients had a normal neurological examination before randomization. Patients were randomized to receive the ataxine plus (ataxine alone) placebo, alone or ataxine plus placebo and for 4 weeks. The study was approved by Committee on the Use of Drugs in Experimental Studies Humans, and written informed consent was obtained from all patients. other study procedures were approved by the University of Where is the cheapest pharmacy to get adderall Washington Institutional Review Board. At baseline and week 1, the drug treatment arm was composed of the same patient population as in the ataxine plus and placebo for 4 weeks analyses. At week 1, the drug treatment arm was changed to include buy real phentermine online uk patients receiving ataxine plus ataxine, as well patients receiving ataxine alone plus placebo. At week 2, the drug treatment arm was changed to include patients receiving ataxine alone plus placebo, as well patients receiving ataxine alone plus ataxine. At week 4, the drug treatment arm was changed to include patients receiving ataxine alone plus ataxine. At week 8, the study was stopped for safety purposes, and all patients were treated with ataxine alone, plus ataxine, or placebo (ataxine placebo). For the purpose of safety analyses, there are no data points in the time course from weeks 1 through 4. Statistical Analysis The study's primary outcome was change in the Modified Rankin Scale score from baseline to week 4. The modified Rankin Scale score is a measure of cognitive decline that is more sensitive than the Alzheimer Disease Assessment Scale-Cognitive Subscale (ADAS-Cog) to detect cognitive change associated with aging. The modification of Rankin Scale score is the ratio of maximal change in the modified Rankin Scale score from baseline to week 4 the maximal change in ADAS-Cog score from baseline to week 4. This ratio suggests the extent of cognitive decline. modified Rankin Scale score is more sensitive generic cialis canada online pharmacy to the effects of treatment than ADAS-Cog score. A total of 538 patients were enrolled, whom 518 completed the study. The primary analysis of this study involved the analyses from week 4. primary analysis used the intention-to-treat approach, in which all participants who were randomized to a treatment arm were included in the analysis. primary analysis included age, sex, race, education, smoking status, and baseline cognition. The study's secondary outcome was difference between the modified Rankin Scale score at week 4 in the drug treatment arm versus placebo arm. Because of the potential for bias related to the use of modified Rankin Scale score as an outcome measure, the modified Rankin Scale score was analyzed by two-stage random-effects models, with the first-stage analysis controlled for remaining study variables in the primary analysis. second-stage analysis controlled for the remaining study variables in a post hoc analysis using the Bonferroni correction for multiple comparisons. All analyses were conducted using Stata v. 9.1 (StataCorp LP, College Station, Texas). All results are presented as mean ± SE unless otherwise noted. Results Figure 1 summarizes patient demographics, baseline cognition, and outcome data from the open-label extension of ataxine plus study. The distribution of baseline scores and the modified Rankin Scale score for each patient was shown in Table 1. The modified Rankin Scale score was significantly lower in the drug treatment arm at week 4 than in the placebo arm. median modified Rankin Scale score decreased from −6.5 to −5.2, which is consistent with the treatment effects seen in results of the pre-specified secondary analysis. Figure 1. View largeDownload slide Baseline demographics and cognitive change from baseline to week 4 and placebo for patients receiving ataxine plus (at)
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